A Time for Metabolism and Hormones.
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| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing AG,
2016.
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| Edition: | 1st ed. |
| Series: | Research and Perspectives in Endocrine Interactions Series
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| Subjects: | |
| Online Access: | Click to View |
Table of Contents:
- Intro
- Preface
- Acknowledgements
- Contents
- List of Contributors
- The Epigenetic and Metabolic Language of the Circadian Clock
- Introduction
- Chromatin Remodeling, Cyclic Transcription and the Clock
- Cellular Metabolism and the Circadian Clock Converge
- The Central Role of Sirtuins
- Conclusion
- References
- Molecular Architecture of the Circadian Clock in Mammals
- Introduction
- Structural Biology of Clock Proteins
- Transcriptional Architecture and Chromatin Dynamics of the Clock
- References
- Circadian Mechanisms in Bioenergetics and Cell Metabolism
- Genetic Approaches to Dissecting Circadian Physiology
- Clock-NAD+-Sirtuin Pathway in Bioenergetics
- Reciprocal Control of the Clock by Nutrient
- Summary and Future Directions
- References
- Control of Metabolism by Central and Peripheral Clocks in Drosophila
- Use of Drosophila to Study Behavior and Metabolic Function
- The Drosophila Fat Body Contains a Clock that Regulates a Rhythm of Feeding
- Fat Body and Neuronal Clocks Coordinately Regulate Metabolic Parameters
- Rhythmic Gene Expression in the Fat Body Is Controlled Largely, but not Exclusively, by the Fat Body Clock
- A Restricted Feeding Paradigm Resets the Phase of Cyclic Gene Expression in the Fat Body but not in the Brain
- Decoupling Peripheral and Brain Tissues Decreases Reproductive Fitness
- Metabolic Signals Also Affect Clocks in the Brain
- References
- Circadian Post-transcriptional Control of Metabolism
- Introduction
- Post-transcriptional Mechanisms
- Circadian Control of poly(A) Tail Length
- Nocturnin Is a Circadian Deadenylase
- Loss of Nocturnin Results in Broad Metabolic Changes
- Conclusions
- References
- Redox and Metabolic Oscillations in the Clockwork
- Introduction
- Challenging Transcriptional Models of the Clockwork
- Non-transcriptional Clock Mechanisms.
- PRDX Rhythms
- Redox and Metabolic Clocks in Eukaryotes
- Conclusion
- References
- Rev-erbs: Integrating Metabolism Around the Clock
- Introduction
- Repression of Transcription by Rev-erbs
- Circadian Biology of Rev-erbs
- Rev-erbĪ± and Metabolism
- Conclusions
- References
- Control of Sleep-Wake Cycles in Drosophila
- Background
- Layout of the Network in Constant Conditions
- Network Architecture Under LD Cycles
- References
- Circadian Metabolomics: Insights for Biology and Medicine
- Introduction: A Many-Clock Problem
- An Overview of Circadian Metabolomics
- Metabolomics: Applications for Circadian Medicine
- Outlook and Conclusion
- References
- Rhythms Within Rhythms: The Importance of Oscillations for Glucocorticoid Hormones
- Introduction
- The Origin of HPA Pulsatility
- Implications of HPA Pulsatility
- Adrenal Adaptation to Pulsatile ACTH
- Tissue Adaptation to Pulsatile CORT
- Conclusion
- References
- The Genetics of Autism Spectrum Disorders
- Introduction
- Twin and Family Studies in ASD
- From Chromosomal Rearrangements to Copy Number Variants in ASD
- From Candidate Genes to Whole Exome/Genome Sequencing Studies in ASD
- The Common Variants in ASD
- The Genetic Architecture of ASD
- The Biological Pathways Associated with ASD
- The Serotonin-NAS-Melatonin Pathway
- Perspectives
- References
- Index.