Cover Image

Self-Assembled Molecules - New Kind of Protein Ligands : Supramolecular Ligands.

Bibliographic Details
Main Author: Roterman, Irena.
Other Authors: Konieczny, Leszek.
Format: eBook
Language:English
Published: Cham : Springer International Publishing AG, 2017.
Edition:1st ed.
Subjects:
Electronic books.
Online Access:Click to View
Table of Contents:
  • Intro
  • Foreword
  • Acknowledgements
  • Contents
  • Abbreviations
  • Chapter 1: Supramolecular Systems as Protein Ligands
  • 1.1 Mechanism of Complexation
  • 1.2 Structural Adaptability of Molecules Forming Supramolecular Structures
  • 1.3 Specificity of Congo Red Complexation
  • References
  • Chapter 2: Supramolecular Congo Red as Specific Ligand of Antibodies Engaged in Immune Complex
  • 2.1 Looking for Evidence of Postulated Intra-molecular Immunological Signaling
  • 2.2 Evidences of Intramolecular Signaling Supplied by Using Congo Red
  • 2.3 Application of Congo Red for Immunotargeting
  • 2.4 Toxicity of CR and Its Applicability for Immunotargeting
  • References
  • Chapter 3: Protein Conditioning for Binding Congo Red and Other Supramolecular Ligands
  • 3.1 Natural Susceptibility of Proteins to Bind Congo Red
  • 3.2 Interaction of Congo Red with Helical Structures of Polypeptides
  • 3.3 Fluorescence Property of Congo Red
  • References
  • Chapter 4: Metal Ions Introduced to Proteins by Supramolecular Ligands
  • 4.1 Metal Ions in Natural Biological Systems
  • 4.2 Insertion of Metal Ions into Proteins by Supramolecular Ligands
  • 4.3 Conclusions
  • References
  • Chapter 5: Possible Mechanism of Amyloidogenesis of V Domains
  • 5.1 Characteristics of Immunoglobulin Domains
  • 5.2 Target Proteins
  • 5.3 The Fuzzy Oil Drop Model
  • 5.4 Structure of Hydrophobic Core in B-J Proteins
  • 5.4.1 Dimers of L-L Chains in Bence-Jones Proteins and of L-H Chains in the Fab Fragment
  • 5.4.2 V(L)-V(L), C(L)-C(L), V(H)-V(L) and C(H)-C(L) Dimers
  • 5.4.3 Individual Domains
  • 5.5 Role of the N-Terminal Fragment in V Domains
  • 5.6 Hypothetical Amyloidogenesis Mechanism Affecting the V Domain in B-J Proteins
  • 5.7 Complexation of Congo Red
  • 5.8 Hypothetical Amyloidogenesis of V Domains
  • References.
  • Chapter 6: Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy
  • 6.1 Introduction
  • 6.2 Silver Complexes with TY in the Supramolecular CR System
  • 6.3 Antimicrobial and Antifungal Activity of Silver Ion Complexes with Titan Yellow (TY/Ag+) and TY/Ag+ Complexes with Congo Red (CR/TY/Ag+)
  • 6.3.1 Methodology
  • 6.3.2 Results
  • 6.4 Determination of the Effect of TY/Ag+ and CR/TY/Ag+ on Antibiotic Activity on Selected Standard and Clinical Bacterial Strains
  • 6.5 Cytotoxicity Analysis of the TY/Ag+ Complex
  • 6.6 Summary
  • References
  • Chapter 7: Congo Red Interactions with Single-Walled Carbon Nanotubes
  • 7.1 Methods of Dispersing Carbon Nanotubes - The Search for Optimal Dispersion Methods
  • 7.2 The Interaction of Congo Red with Carbon Nanotubes
  • 7.3 The Incorporation of Other Compounds by SWNT-CR Complexes - Examples of Possible Biomedical Use
  • References
  • Erratum
  • Index.

Similar Items