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Advancing the Science of Cancer in Latinos.

Bibliographic Details
Main Author: Ramirez, Amelie G.
Other Authors: Trapido, Edward J.
Format: eBook
Language:English
Published: Cham : Springer International Publishing AG, 2019.
Edition:1st ed.
Subjects:
Electronic books.
Online Access:Click to View
Table of Contents:
  • Intro
  • Preface
  • Acknowledgments
  • Contents
  • Contributors
  • About the Editors
  • Part I: Introduction
  • Chapter 1: Advancing the Science of Cancer in Latinos
  • Introduction
  • Part II: Genetics, Environment, Lifestyle, and Cancer
  • Part III: Cancer Risk, Prevention, and Screening
  • Part IV: The Biology of Cancer Health Disparities
  • Gastric Cancer
  • Breast Cancer
  • Part V: Advances in Cancer Therapy and Clinical Trials
  • Part VI: Cancer in the Era of Precision Medicine
  • Part VII: Cancer Outcomes and Survivorship in Latinos
  • Part VIII: Engaging Latinos in Cancer Research
  • Conclusion
  • References
  • Part II: Genetics, Environment, Lifestyle, and Cancer
  • Chapter 2: Disaggregated Hispanic Groups and Cancer: Importance, Methodology, and Current Knowledge
  • Introduction
  • Epidemiology of Cancer in Hispanics: Aggregated
  • Epidemiology of Cancer in Disaggregated Hispanic Groups
  • Challenges in the Data
  • Challenges in the Analyses
  • Survival Estimation Problems for Disaggregated Hispanic Groups
  • Current Knowledge: Cancer in Hispanic Groups, Based on Mortality Data
  • Conclusions
  • References
  • Chapter 3: Colorectal Cancer Disparities in Latinos: Genes vs. Environment
  • Overview of Colorectal Cancer Disparities in Hispanics
  • Factors Contributing to Colorectal Cancer Disparities in Puerto Rican Hispanics
  • Epidemiology
  • Environmental Factors
  • Genetics
  • Summary
  • References
  • Part III: Cancer Risk, Prevention, and Screening
  • Chapter 4: Breast Cancer Risk and Mortality in Women of Latin American Origin
  • Introduction
  • Breast Cancer Risk in Women of Latin American Origin
  • Breast Cancer Mortality in Women of Latin American Origin
  • Breast Tumor Subtypes in Women of Latin American Origin.
  • Gaps: Do We Have the Right Data to Learn to Predict, Prevent, and Treat Breast Cancer in Women of Latin American Origin?
  • References
  • Chapter 5: Prostate Cancer in US Latinos: What Have We Learned and Where Should We Focus Our Attention
  • Prostate Cancer Among Latinos
  • Prostate Cancer Incidence and Etiology
  • Clinical Presentation of PCa Among Latinos
  • PCa Treatment Patterns Among Latinos
  • Survival and Mortality
  • Final Conclusions and Key Knowledge Gaps to Address
  • References
  • Chapter 6: Differential Cancer Risk in Latinos: The Role of Diet
  • Introduction
  • Cancer Incidence Varies by Ethnicity and Gender
  • Dietary Factors and Cancer Risk
  • Dietary Patterns and Cancer Risk
  • References
  • Part IV: The Biology of Cancer Health Disparities
  • Chapter 7: Biomarkers of Gastric Premalignant Lesions
  • Epidemiology
  • Etiology
  • H. pylori
  • Environmental Factors
  • Genetic Bases of the Gastric Inflammatory Cascade (Correa's Cascade)
  • Single-Nucleotide Polymorphisms (SNPs)
  • Stage-Specific and Evolution-Associated Gene Profiles
  • References
  • Chapter 8: Molecular Subtypes and Driver Mutations in Latinos with Gastric Cancer: Implications for Etiological and Translational Research
  • Gastric Cancer Is a Common Malignancy with Poor Outcomes
  • Gastric Cancer in Latinos
  • Genomic and Genetic Research Disparities
  • The Unique Epidemiology of Gastric Cancer in Latinos
  • Molecular GC Profiles in Latinos Are Unique
  • Conclusions
  • References
  • Chapter 9: The Biology of Breast Cancer Disparities in Hispanics: Current Knowledge, Gaps, and Research Opportunities
  • Introduction
  • Factors Contributing to Higher Breast Cancer Mortality Among Hispanics
  • Recent Data Elucidating the Causes of Breast Cancer Disparities Among Hispanics
  • Breast Cancer in Young Hispanic Women: The Subset with the Greatest Disparities in Outcomes.
  • Conclusions from Recent Data
  • Hypothesis for the Causes of Early Onset Breast Cancer Disparities and the Potential Role of Childhood Obesity
  • Childhood Obesity: A Likely Contributor to Breast Cancer Disparities
  • Possible Linkage of Childhood Obesity with Breast Cancer: The Third Harvard Growth Study
  • Childhood Obesity: A Proinflammatory State with High Estrogen and Genotoxic Estrogen Levels
  • Contemporary Hormonal Contraception Is Associated with a Higher Risk of Breast Cancer
  • Oral Versus Transdermal Estrogen Replacement and Its Effects on Estrogen Metabolism
  • Future Research on Genotoxic Estrogen Metabolites and Breast Cancer Disparities
  • Conclusions
  • References
  • Chapter 10: Molecular Profiles of Breast Cancer in Hispanic/Latina
  • Introduction
  • Breast Cancer Intrinsic Subtypes
  • Genetic Ancestry and Breast Cancer Characteristics
  • Conclusions
  • References
  • Part V: Advances in Cancer Therapy and Clinical Trials
  • Chapter 11: Biomarkers and Precision Medicine in Oncology Practice and Clinical Trials
  • Introduction: Biomarkers in Clinical Care and Research
  • Biomarker-Based Precision Medicine
  • Biomarkers for Decision Support
  • Biomarker Properties
  • Considerations in Biomarker-Driven Trial Design
  • Tumor Sequencing for the Near Future
  • FDA Approvals of Next-Generation Gene Sequencing (NGS) Panels and In Vitro Diagnostics (IVDs)
  • Designing Clinical Trials to Support FDA Approval
  • Cancer Immunotherapy (CIT) Biomarkers
  • General Concepts
  • Program for Accelerated Cancer Therapies (PACT): An Example of Multidisciplinary Collaboration to Elucidate Relevant Biomarkers in Oncology
  • Challenges and Opportunities to Improve Biomarker-Based Trials
  • Chapter 12: Overcoming Barriers for Latinos on Cancer Clinical Trials
  • Increasing Complexity of Accrual in Clinical Trials for All Populations.
  • Barriers That May Disproportionately Impact Latino Patient Enrollment
  • Strategies to Facilitate Clinical Trial Participation
  • Next Steps
  • References
  • Part VI: Cancer in the Era of Precision Medicine
  • Chapter 13: Breast Cancer Precision Medicine in Hispanics/Latinas: Focus on Luminal B Tumors
  • Introduction
  • Hispanics/Latinas and Breast Cancer: A Complex Relationship
  • Luminal B Breast Cancer in Colombians
  • Discussion
  • References
  • Chapter 14: Is Precision Medicine Widening Cancer Care Disparities in Latino Populations? The Rutgers Cancer Institute of New Jersey Experience
  • Introduction
  • Background
  • Latino Populations in the United States
  • Latino Populations in New Jersey
  • Targeted Therapies as Standard of Care
  • Cancer Incidence and Mortality Rates Among Patients of Latino Ancestry
  • Our Experience
  • Next-Generation Sequencing (NGS)
  • Results
  • Discussion
  • References
  • Part VII: Cancer Outcomes and Survivorship in Latinos
  • Chapter 15: A Vision for Improving Quality of Life Among Spanish-Speaking Latina Breast Cancer Survivors
  • Introduction
  • State of the Science on Behavioral Interventions to Improve Health-Related Quality of Life Among Latino Cancer Survivors
  • The Nuevo Amanecer Program and Translation Methods
  • Rationale
  • Translation of the Nuevo Amanecer Program
  • A Conceptual Framework to Guide Research on Behavioral Interventions for Latino Cancer Survivors
  • Gaps and Opportunities for Future Research
  • Conclusions
  • References
  • Chapter 16: Research Democracy in a Randomized Controlled Trial: Engaging Multiple Stakeholders in Patient-Centered Outcomes Research
  • Introduction
  • Methods
  • Results
  • Discussion
  • References
  • Part VIII: Engaging Latinos in Cancer Research
  • Chapter 17: Es Tiempo: Engaging Latinas in Cervical Cancer Research
  • Overview of Community-Driven Research.
  • Current Work
  • Past Interventions
  • Tamale Lesson: Transforming Cancer Information Through Narrative
  • Es Tiempo: The Jacaranda Initiative
  • Identified Gaps
  • Future Research
  • References
  • Chapter 18: Reaching Latinos Through Social Media and SMS for Smoking Cessation
  • Background
  • Methods
  • Program Development
  • Pretesting
  • Process
  • Program Promotion
  • Results and Discussion
  • Conclusion
  • References
  • Chapter 19: The Need for a Holistic Approach to Prevent Reproductive Cancers Among US Latinas: The Potential Impact of Normalizing Sexuality and Improving Communication
  • Introduction
  • Study 1
  • Materials, Procedure, and Approach to Analysis
  • Results
  • Study 2
  • Materials, Procedure, and Approach to Analysis
  • Results
  • Discussion
  • References
  • Chapter 20: Critical Steps for Engaging Hispanics in Cancer Research: Building Capacity to Enhance Participation in Biospecimen Donation with Hispanic Communities
  • Introduction
  • Three Critical Steps for Engaging Hispanics in Cancer Research
  • Step 1: Know the Community
  • Step 2: Know the Goal of Engagement Activities
  • Step 3: Design Activities Using Best Practice Strategies
  • Discussion and Lessons Learned
  • References
  • Part IX: Charting the Future of Cancer Health Disparities Research in Latinos
  • Chapter 21: Emerging Policies in US Health Care
  • Congressman Joaquin Castro, Representative from the 20th Congressional District in Bexar County, Texas
  • Dr. Esteban López, Chief Medical Officer, Clinical Strategy and Innovation at Blue Cross and Blue Shield of Texas
  • Dr. Robert Croyle, Director, Division of Cancer Control and Population Sciences at the National Cancer Institute
  • Dr. Elena Rios, President and CEO of the National Hispanic Medical Association
  • Congressional Legislation in the 115th Congress (January 3, 2017 to January 3, 2019).
  • Health Policy Trends.

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