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Make Life Visible.

Bibliographic Details
Main Author: Toyama, Yoshiaki.
Other Authors: Miyawaki, Atsushi., Nakamura, Masaya., Jinzaki, Masahiro.
Format: eBook
Language:English
Published: Singapore : Springer Singapore Pte. Limited, 2019.
Edition:1st ed.
Subjects:
Electronic books.
Online Access:Click to View
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100 1 |a Toyama, Yoshiaki. 
245 1 0 |a Make Life Visible. 
250 |a 1st ed. 
264 1 |a Singapore :  |b Springer Singapore Pte. Limited,  |c 2019. 
264 4 |c ©2020. 
300 |a 1 online resource (285 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
505 0 |a Intro -- Preface -- Contents -- Part I: Visualizing and Controlling Molecules for Life -- Chapter 1: Photoacoustic Tomography: Deep Tissue Imaging by Ultrasonically Beating Optical Diffusion -- Chapter 2: Regulatory Mechanism of Neural Progenitor Cells Revealed by Optical Manipulation of Gene Expressions -- References -- Chapter 3: Eavesdropping on Biological Processes with Multi-dimensional Molecular Imaging -- 3.1 Intravital Imaging -- 3.2 Volumetric Cardiac Imaging in Embryonic Zebrafish -- 3.2.1 Zebrafish As a Model System for Cardiovascular Research -- 3.2.2 Cardiac Development: Symbiosis of Function and Form -- 3.2.3 Cardiac Imaging Is a 4-Dimensional Challenge -- 3.2.4 Principles of Cardiac Gated Imaging in Zebrafish -- 3.2.4.1 Prospective Gating -- 3.2.4.2 Retrospective Gating -- 3.2.4.3 Macroscopic Phase Stamping -- 3.3 Large Scale In Vivo Brain Imaging with Two-Photon Light-Sheet Microscopy -- 3.3.1 Brain Activity Monitoring in Behaving Zebrafish -- 3.3.2 Principles and Successes of Light-Sheet Microscopy for Zebrafish Brain Imaging -- 3.4 Conclusion -- References -- Chapter 4: Apical Cytoskeletons Help Define the Barrier Functions of Epithelial Cell Sheets in Biological Systems -- 4.1 Introduction -- 4.2 The Apical Cytoskeletons in General Epithelial Cells -- 4.3 The Apical Cytoskeletons in Multiciliated Cells, a Possible Extreme Example of a "TJ-Apical Complex" with a Clear Function -- 4.4 Perspective -- References -- Chapter 5: Neural Circuit Dynamics of Brain States -- References -- Online Resources -- Chapter 6: Optogenetic Reconstitution: Light-Induced Assembly of Protein Complexes and Simultaneous Visualization of Their Intracellular Functions -- 6.1 Introduction -- 6.2 Light-Induced Heterodimerization Tools -- 6.3 Visualization Tools Compatible with Optogenetic Manipulation. 
505 8 |a 6.4 Light-Induced Assembly/Reconstitution of Force-Generating Complexes During Mitosis -- 6.5 Perspectives -- References -- Chapter 7: 19F MRI Probes with Tunable Chemical Switches -- 7.1 Magnetic Resonance Imaging -- 7.2 Perfluorocarbon Encapsulated in Silica Nanoparticle (FLAME) -- 7.3 Paramagnetic Relaxation Enhancement (PRE) Effect -- 7.4 Gadolinium Based-19F MRI Nanoprobe for Monitoring Reducing Environment -- References -- Chapter 8: Circuit-Dependent Striatal PKA and ERK Signaling Underlying Action Selection -- References -- Chapter 9: Making Life Visible: Fluorescent Indicators to Probe Membrane Potential -- 9.1 Introduction -- 9.2 Rational Design of VoltageFluor Dyes -- 9.3 Voltage Imaging with Red-Shifted Dyes -- 9.4 Far-Red Voltage Imaging for High Sensitivity -- 9.5 Accessing Two-Photon Infrared Excitation for Imaging in Thick Brain Tissue -- 9.6 Targeting VoltageFluor Dyes to Specific Cells -- 9.7 Conclusion/Summary -- References -- Chapter 10: Molecular Dynamics Revealed by Single-Molecule FRET Measurement -- 10.1 Single-Molecule Fluorescence Imaging -- 10.2 Molecular Dynamics of Proteins Measured by smFRET -- 10.3 Advances in smFRET Methods -- 10.4 Conclusion -- References -- Chapter 11: Comprehensive Approaches Using Luminescence to Studies of Cellular Functions -- 11.1 &lt -- Fluoppi&gt -- -- 11.2 &lt -- Fucci&gt -- -- 11.3 &lt -- GEPRA&gt -- -- 11.4 &lt -- UnaG&gt -- -- References -- Part II: Imaging Disease Mechanisms -- Chapter 12: Making Chronic Pain Visible: Risks, Mechanisms, Consequences -- 12.1 Summary Abstract for Presentation Delivered at Uehara Meeting, June 2017 -- Chapter 13: Visualization of the Pathological Changes After Spinal Cord Injury (-From Bench to Bed Side-) -- 13.1 Diffusion Tensor Tractography -- 13.1.1 Basic Research -- 13.1.2 Clinical Significance of DTT -- 13.2 Myelin Map -- 13.2.1 Basic Research. 
505 8 |a 13.2.2 Clinical Significance of Myelin Map -- 13.3 Resting-State Functional MRI -- References -- Chapter 14: Multimodal Label-Free Imaging to Assess Compositional and Morphological Changes in Cells During Immune Activation -- References -- Chapter 15: Investigating In Vivo Myocardial and Coronary Molecular Pathophysiology in Mice with X-Ray Radiation Imaging Approaches -- 15.1 Translating Imaging of Cardiac Function to Small Animals -- 15.2 The Importance of the Microvessels in Sustaining Cardiac Function -- 15.2.1 The Challenges Associated with Investigating Coronary Microvascular Function -- 15.2.2 Protocols for Assessment of Coronary Endothelial Function -- 15.3 Progress in Vascular Imaging of Small Animals with Lab Systems -- 15.4 Application of In Vivo SAXS to the Study of Myocardial Function in Mice -- References -- Chapter 16: Visualizing the Immune Response to Infections -- Chapter 17: Imaging Sleep and Wakefulness -- 17.1 Introduction: Behavioral Definition of Sleep -- 17.2 Oscillations in Sleep -- 17.3 Electrophysiological Insights into the Sleeping Brain -- 17.4 Imaging Techniques Show Novel Aspects of Sleep -- 17.5 Future Directions -- References -- Chapter 18: Abnormal Local Translation in Dendrites Impairs Cognitive Functions in Neuropsychiatric Disorders -- 18.1 Introduction -- 18.2 Results -- 18.2.1 TDP-43 Forms Co-Aggregates with DISC1 in Neurons -- 18.2.2 Role of DISC1 in Local Translation in Dendrites -- 18.2.3 TDP-43-DISC1 Co-Aggregation Inhibits Local Translation in Dendrites -- 18.2.4 DISC1-Dependent Behavioral Impairment and Rescue in TDP-220C Mice -- 18.3 Discussion -- References -- Chapter 19: Imaging Synapse Formation and Remodeling In Vitro and In Vivo -- 19.1 Synapse, Neuron, and Neural Network -- 19.2 In Vitro Imaging of Dynamic Synapses -- 19.3 In Vivo Imaging of Dynamic Synapses. 
505 8 |a 19.4 In Vivo Imaging of Neocortical Circuits in Mouse Models of Developmental Disorders -- 19.5 Perspectives -- References -- Part III: Imaging-Based Diagnosis and Therapy -- Chapter 20: How MRI Makes the Brain Visible -- 20.1 Progress of Imaging to Investigate the Anatomy of the Brain -- 20.2 Imaging Brain Function with Functional MRI (fMRI) -- 20.3 Imaging Brain Tissue Microstructure with Diffusion MRI (dMRI) -- 20.4 Future of MRI -- References -- Chapter 21: Application of Imaging Technology to Humans -- 21.1 Introduction -- 21.2 MPM Technique Enables to Visualize the Histological Features of Fresh, Unstained Human Colorectal Mucosa and Can Be Used for Histopathological Diagnoses -- 21.3 Classification by Numerical Parameters Enables to Distinguish NL-MPM Images to Normal and Cancerous Tissues Quantitatively -- 21.4 Conclusion -- References -- Chapter 22: Theranostic Near-Infrared Photoimmunotherapy -- 22.1 Introduction -- 22.2 NIR-PIT Can Selectively Kill Various Cancer Cells -- 22.3 NIR-PIT Rapidly Enhances Nano-Drug Delivery -- 22.4 NIR-PIT Initiates Anti-Tumor Host Immunity and Promotes Rapid Healing -- 22.5 Targeting Systemic Metastases -- 22.6 Perspective -- References -- Chapter 23: Integrated Imaging on Fatigue and Chronic Fatigue -- 23.1 Introduction -- 23.2 Integrated Imaging Studies -- 23.3 PET Studies -- 23.4 MRI Morphometry -- 23.5 fMRI Study -- 23.6 MEG Study -- References -- Chapter 24: Development of Novel Fluorogenic Probes for Realizing Rapid Intraoperative Multi-color Imaging of Tiny Tumors -- 24.1 Rational Design of Organic Fluorogenic Probes Based on Unique Spirocyclization of Rhodamines by the Intramolecular Hydroxymethyl Group -- 24.2 Development of Novel Fluorogenic Green Probes for Biological and Medical Purposes, Especially for Intraoperative Rapid Tumor Imaging. 
505 8 |a 24.3 Development of Novel Fluorogenic Scaffold for Detecting Protease Activity in Longer Wavelength by Optimizing the Spirocyclization Properties: Novel Strategy for Fluorescence-Assisted Surgery with Multicolor Protease Imaging (Iwatate et al. 2016 -- 24.4 Conclusion -- References -- Chapter 25: Coronary Heart Disease Diagnosis by FFRCT: Engineering Triumphs and Value Chain Analysis -- 25.1 Coronary Heart Disease Pathophysiology -- 25.2 Invasive Coronary Angiography Is Inefficient -- 25.3 Fractional Flow Reserve -- 25.4 CT Angiography -- 25.5 Comparing Costs -- 25.6 Economic Considerations for Translation to Routine Care -- 25.7 Conclusion -- References -- Chapter 26: Live Imaging of the Skin Immune Responses -- 26.1 Introduction -- 26.2 The Skin and Its Key Immune Cells -- 26.2.1 Dendritic Cells -- 26.2.2 Neutrophils -- 26.2.3 Macrophages -- 26.2.4 Mast Cells -- 26.2.5 T Cells -- 26.3 Tools for In Vivo Imaging -- 26.3.1 Microscopy -- 26.3.2 Animal Systems and Fluorescent-Cell Labelling Techniques -- 26.4 In vivo Imaging of Skin Immune Responses -- 26.4.1 Sterile Injury -- 26.4.2 Contact Hypersensitivity -- 26.4.3 Infection -- 26.4.4 Cancer -- 26.5 Concluding Remarks - Looking Ahead to the Future -- References -- Chapter 27: Development of Upright CT and Its Initial Evaluation: Effect of Gravity on Human Body and Potential Clinical Application -- 27.1 X-Ray Imaging of the Human Body -- 27.2 Cross-Sectional Imaging of Human Body -- 27.3 Development of Upright CT -- 27.4 Physical Properties and Clinical Data Analysis -- References -- Chapter 28: The Future of Precision Health &amp -- Integrated Diagnostics -- Reference -- Chapter 29: Imaging and Therapy Against Hypoxic Tumors with 64Cu-ATSM -- 29.1 Radiolabeled Cu-ATSM as a Hypoxia Imaging Agent for PET -- 29.2 64Cu-ATSM as a Theranostic Agent -- 29.3 64Cu-ATSM Theranostics for Cancer Stem Cells. 
505 8 |a 29.4 Biodistribution and Dosimetry of 64Cu-ATSM. 
588 |a Description based on publisher supplied metadata and other sources. 
590 |a Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2023. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.  
655 4 |a Electronic books. 
700 1 |a Miyawaki, Atsushi. 
700 1 |a Nakamura, Masaya. 
700 1 |a Jinzaki, Masahiro. 
776 0 8 |i Print version:  |a Toyama, Yoshiaki  |t Make Life Visible  |d Singapore : Springer Singapore Pte. Limited,c2019  |z 9789811379079 
797 2 |a ProQuest (Firm) 
856 4 0 |u https://ebookcentral.proquest.com/lib/matrademy/detail.action?docID=5941324  |z Click to View 

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