Biomarkers of Inflammation and Intestinal Mucosa Pathology in Celiac Disease.
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Linköping :
Linkopings Universitet,
2019.
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| Edition: | 1st ed. |
| Series: | Linköping University Medical Dissertations Series
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| Subjects: | |
| Online Access: | Click to View |
Table of Contents:
- Intro
- Abstract
- Biomarkörer vid celiaki
- List of publications
- Abbreviations
- Contents
- Introduction
- Celiac disease
- Epidemiology
- Genetics
- Environmental factors
- Effects of celiac disease in the small intestine
- Intestinal mucosa
- Gluten
- Pathogenesis
- Effects of celiac disease in blood
- Extra-intestinal manifestations of celiac disease
- Celiac disease diagnostics, treatment, and follow-up
- Histopathology
- Antibody levels
- HLA typing
- Current recommended diagnostic flow
- Celiac disease treatment
- Celiac disease follow-up
- Conditions with intestinal symptoms similar to celiac disease
- Gene expression
- Biomarkers for celiac disease
- Methods - general overview
- RNA and DNA isolation
- Real-time PCR and TaqMan technology
- Relative quantitative real-time PCR
- Massive parallel sequencing
- RNA sequencing
- Enzyme-linked immunosorbent assay
- Luminex xMAP technology
- Genotyping
- Genotyping using a sequence-specific primer PCR method
- Genotyping using real-time PCR and TaqMan probes
- Thesis aims
- Methods - study specific
- Study subjects and groups
- Biopsy and blood sampling
- Statistical methods and tools
- Paper I
- Sample preparations
- Gene expression analysis
- Statistical analysis
- Paper II
- Sample preparations
- Gene expression analysis
- Protein quantification
- Genotyping
- Statistical analysis
- Paper III
- Sample preparations
- Gene expression analysis
- Genotyping
- Statistical analysis
- Paper IV
- Sample preparations
- Gene expression analysis
- Genotyping
- Statistical analysis
- Results and analysis
- Papers I and III - Gene expression analysis in small intestinal biopsies
- Papers II and IV - RNA and protein levels in blood
- Discussion
- Conclusions
- Thesis contribution and future perspectives
- Acknowledgements
- References.