Stem Cells in Neuroendocrinology.
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| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing AG,
2016.
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| Edition: | 1st ed. |
| Series: | Research and Perspectives in Endocrine Interactions Series
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| Subjects: | |
| Online Access: | Click to View |
Table of Contents:
- Intro
- Introduction
- Acknowledgments
- Contents
- List of Contributors
- A Brief Overview of Techniques for Modulating Neuroendocrine and Other Neural Systems
- A Brief View of the Oldest, Most Primitive Approaches
- The Disciplines
- Morphology
- Physiology
- Chemistry
- Genetics, Genomics
- Cognitive Neuroscience
- Computational Approaches
- A Brief Survey of Emerging Techniques for Neuromodulation
- Electrical
- Chemical
- Genetic
- Viral
- Computational
- Special Opportunities for Manipulating the Unique Products of Neuroendocrine Neurons
- This Volume
- Further Reading
- Basics of Stem Cell Biology as Applied to the Brain
- Introduction
- The Basic Biology of Stem Cells
- Preimplantation Development and Embryonic Stem (ES) Cells
- Derivation and Maintenance of Pluripotent Stem Cells: Differences Between Mouse and Human
- How to Test Pluripotency?
- Opportunities and Challenges for Using ES Cells in Medicine
- Obtaining Cells Genetically Matched to Patients: Reprogramming, Cloning, and Induced Pluripotent Stem Cells
- Opportunities and Challenges of Producing Hypothalamic Neurons from Stem Cells
- Direct Reprogramming: An Alternative Pathway to Obtaining Patient-Matched Neuron-Like Cells
- Relevance of In Vitro Cell Types to Neuronal Biology
- Outlook
- References
- Human Pluripotent-Derived Lineages for Repairing Hypopituitarism
- Derivation of Human Neural Cell Types for Regenerative Medicine
- Derivation and Application of Human Pituitary Lineages
- Perspectives and Challenges on the Road to Translation
- Conclusion
- References
- Recapitulating Hypothalamus and Pituitary Development Using Embryonic Stem/Induced Pluripotent Stem Cells
- Introduction
- A Need for Hypothalamus and Adenohypophysis Regenerative Medicine
- Mouse ES Cells
- Pituitary Gland Embryology.
- Three-Dimensional ES Cell Culture
- Induction of Hypothalamic Neurons from Mouse ES Cells
- Two-Layer Formation In Vitro Is the First Step of Adenohypohysis Differentiation
- Self-Formation of Rathkeś Pouch
- Differentiation Into Hormone-Producing Endocrine Cells
- Functionality of Induced ACTH+ Cells
- Effect of Transplantation Into Hypophysectomized Model Animals
- Adaptation to Human ES/iPS Cell Culture
- Future Perspectives
- References
- Regulation of Body Weight and Metabolism by Tanycyte-Derived Neurogenesis in Young Adult Mice
- Introduction
- Material and Methods
- Animals
- Caloric Restriction
- Reagents
- Bromodeoxyuridine (BrdU)
- Tissue Processing and Antibodies
- Immunohistochemistry
- Cell Quantification
- Focal Irradiation of Ventrobasal Hypothalamus
- Longitudinal Collection of Weight Data
- Statistical Analysis
- Results
- Dietary Signals Differentially Regulate Neurogenesis and Cell Proliferation in ME and ArcN
- Sex-Specific Differences in Diet-Induced Hypothalamic Neurogenesis
- Blocking Neurogenesis in ME Attenuates HFD-Induced Weight Gain in Young Adult Female, But Not Male, Mice
- Discussion
- References
- Genetic Dissection of the Neuroendocrine and Behavioral Responses to Stressful Challenges
- References
- Pituitary Stem Cells: Quest for Hidden Functions
- Introduction
- Primer on Pituitary Biology and Pathology
- Pituitary Stem Cells: Expanding Molecular Portrayal
- Pituitary Stem Cells: Uncovering the Hidden Functions
- Neonatal Pituitary Maturation
- Basal and Adapting Adult Pituitary
- Pituitary Regeneration and Impact of Aging
- Pituitary Tumorigenesis
- Conclusion and General Perspectives
- References
- Pituitary Stem Cells During Normal Physiology and Disease
- Introduction
- The Long-Term Maintenance of the Anterior Pituitary
- Stem Cells and Pituitary Tumours.
- References
- Epigenetic Mechanisms of Pituitary Cell Fate Specification
- Introduction
- Escaping Stemness
- Intermediate Pituitary Identity
- Pax7 Opens a New Enhancer Repertoire
- The Essence of Pioneering
- Succeeding at Multiple Choices or Avoiding Cellular Schizophrenia
- Future Challenges
- References
- Advances in Stem Cells Biology: New Approaches to Understand Depression
- Introduction
- How Can We Best Study Depression?
- The Neurogenesis Theory of Depression
- Experimental Approaches
- Immortalized Human Neural Cell Lines
- Neural Stem Cell Lines
- Modeling the Role of Stress
- Modeling the Role of Inflammation and Oxidative Stress
- Studying Mechanism of Action of Antidepressants
- Tumour-Derived Cell Lines
- Patient-Derived Neural Cells
- IPSCs
- Olfactory Neuroepithelium-Derived Stem Cells
- Conclusions and Limitations of the Cell Models
- References
- Perspective on Stem Cells in Developmental Biology, with Special Reference to Neuroendocrine Systems
- Introduction
- Morphogenesis of the Hypothalamo-Pituitary Axis (Fig.1)
- Hypothalamus
- Pituitary
- Characterization of AdSC in the Hypothalamo-Pituitary Axis (Fig.3)
- Hypothalamus
- Pituitary
- In vitro Recapitulation of Ontogenesis in the Hypothalamo-Pituitary Axis (Fig.3)
- Induction of Hypothalamic Identity from 3D ESC Aggregates
- Generation of Hypothalamic Neurons from 2D ESC Cultures
- Induction of RP from 3D Aggregates
- Perspectives
- Differentiation Strategies
- Implantation in Homotypic Locations
- Conclusion
- References.