Neuroprotective Effect of Genistein : Studies in Rat Models of Parkinson's and Alzheimer's Disease.
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
Linköping :
Linkopings Universitet,
2012.
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| Edition: | 1st ed. |
| Series: | Linköping University Medical Dissertations Series
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| Subjects: | |
| Online Access: | Click to View |
Table of Contents:
- Genistein inhibits aggregation of exogenous amyloid-beta1-40 and alleviates astrogliosis in the hippocampus of rats
- 1. Introduction
- 2. Results
- 2.1. Sham-operated rats
- 2.2. Sham-operated genistein-treated rats
- 2.3. Aβ-injected rats
- 2.4. Aβ-injected genistein-treated rats
- 2.5. Aβ-injected Cremophor-treated rats
- 3. Discussion
- 3.1. Intrahippocampal injection of Aβ1-40 causes neuronal degeneration in the DGlb
- 3.2. Effect of genistein on formation of Aβ aggregates and neurodegeneration
- 3.3. iNOS, nNOS and astrogliosis
- 4. Experimental procedures
- 4.1. Preparation of Aβ1-40 and genistein
- 4.2. Animals
- 4.3. Surgery
- 4.4. Specimen preparation and histochemistry
- 4.5. Immunohistochemistry
- 4.6. Image analysis of GFAP intensity
- 4.7. Statistical analysis
- Conflict of interest
- Acknowledgments
- References.